Dr. Dritan Agalliu, PhD., Assistant Professor of Pathology and Cell Biology in Neurology and Pharmacology at Columbia University. The Role of Adaptive Immunity in Vascular and Neuronal Dysfunction in Animal Models for PANS/PANDAS. May 15, 2019, 6:00-7:00 pm CST
Dr. Agalliu is an Assistant Professor in the Departments of Neurology, Pathology and Cell Biology and Pharmacology at Columbia University Medical Center. Dr. Agalliu’s research is focused on understanding the cellular and molecular mechanisms that regulate formation of the blood-brain barrier in the central nervous system (CNS) and the mechanisms of barrier breakdown in a variety of CNS diseases such as stroke and autoimmune diseases having symptoms that include blood-brain barrier failure, using a variety of genetic, molecular, cellular and imaging approaches. Dr. Agalliu’s laboratory has developed novel mouse strains to visualize changes in structural components of the blood-brain barrier, namely tight junctions and caveolae, in living animals for several CNS diseases (e.g. stroke and multiple sclerosis) in order to understand the cellular mechanisms underlying barrier impairment in these neurological disorders. In addition, Dr. Agalliu’s laboratory is investigating the role of Wnt/β-catenin signaling in development of the CNS vasculature and formation of the blood-brain barrier, and exploring the role of this pathway in repairing the barrier in diseases where its function is compromised (e.g. stroke and autoimmune disorders). Finally, Dr. Agalliu is investigating the mechanisms of immune cells entry into the CNS in a novel animal model for a neuropsychiatric disorder caused by multiple Streptococcus pyogenes infections, in order to understand how immune cells induce neurovascular, synaptic and behavioral deficits in this disease.
1. Identify the major issues regarding the pathology of PANDAS/PANS and the relationship of PANDAS/PANS to other autoimmune encephalitides syndromes.
2. Understand the role that Th17 lymphocytes play in the vascular and neurological deficits in PANDAS/PANS.
3. Describe the effects of sera obtained from the children suffering from PANDAS/PANS on the blood-brain barrier in vitro.
Dr. Kiki Chang, Child Psychiatrist, Former Professor of Psychiatry and Behavioral Sciences, Stanford, Co-Founder, Stanford PANS Clinic. Review of Expert Consensus Treatment Guidelines for Youth with PANS: Focus on Combining Psychotropics with Medical Treatments. August 27, 2019, 7:00-8:00 pm CST
Dr. Kiki Chang, is a child psychiatrist with over 22 years of experience in working with younger children, adolescents, adults and families. Formerly, Dr. Chang was Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine and co-founder of the Stanford PANS Clinic. His specialty is working with youth and young adults who have or are at risk for serious mood disorders, such as depression or bipolar disorder as well as PANS/PANDAS and related neuropsychiatric disorders. By working with children who have these complex conditions, he has also accumulated extensive experience in working with ADHD, anxiety, behavioral disorders, OCD, tic disorders, psychotic disorders, and autism spectrum disorders. His research has focused on genetic and biological markers, particularly brain imaging, for risk for development of severe mood disorders, and interventions to prevent such disorders from occurring.
1. Understand the role of psychotropic medications in treating youth with PANS/PANDAS.
2. Discuss the different symptoms that present in PANS and how they may overlap with typical psychiatric disorders.
3. Consider appropriate psychiatric treatments and therapies for youth with PANS.
Dr. Richard Frye, MD, PhD. Chief of the Division of Neurodevelopment Disorders, Phoenix Children's Hospital. Understanding The Overlap of PANS and Autism – An Overview of Research on Antineuronal Antibodies in Patients With Autism. March 12, 2019, 7:30-8:30 pm CST
Dr. Richard Frye is a Child Neurologist with expertise in neurodevelopmental and neurometabolic disorders. He received an MD and PhD in Physiology and Biophysics from Georgetown University. He completed a residency in Pediatrics at the University of Miami, Residency in Child Neurology and Fellowship in Behavioral Neurology and Learning Disabilities at Harvard University/Children’s Hospital Boston and Fellowship in Psychology at Boston University. He also received a Masters in Biomedical Science and Biostatistics from Drexel University. He holds board certifications in General Pediatrics, and in Neurology with Special Competence in Child Neurology. He has authored over 150 peer-reviewed publications and book chapters, and serves on several editorial boards. He is conducted several clinical trials demonstrating the efficacy of safe and novel treatments that target underlying physiological abnormalities in children with neurodevelopmental disorders.
Description of Dr. Frye's presentation:
Many autoantibodies have been reported in children with autism spectrum disorder (ASD). Many of these autoantibodies interfere with brain function, resulting in the diagnosis of autoimmune encephalopathy (AIE). Identifying the particularly autoantibodies that cause AIE in ASD and how to treat such abnormalities is an evolving area of medicine. This talk will discuss the autoantibodies associated with AIE in ASD and the latest research regarding potential treatments, including leucovorin calcium and intravenous immunoglobulin (IVIG). This talk will provide an overview on some of the immune mechanism that may be causative of ASD symptoms and an evidence based review of implications for their treatment.
· Discuss the latest research regarding the role of the immune system in autism spectrum disorder (ASD)
· Review current evidence regarding which auto-antibodies may cause significant symptoms in children with ASD
· Discuss research regarding improvement of symptoms caused by auto-antibodies in children with ASD
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Dr. Jennifer Frankovich, MD, PANS Program Director and Associate Professor, Pediatric Rheumatology, Stanford Children's Hospital. PANS: Inflammatory Markers and Co-Morbid Inflammatory Diseases. January 29, 2019, 5:00-6:00 pm CST
Dr. Frankovich is an Associate Clinical Professor in the Department of Pediatrics, Division of Allergy, Immunology Rheumatology (AIR) at Stanford University/Lucile Packard Children’s Hospital (LPCH). Her clinical expertise is in systemic inflammatory and autoimmune diseases that co-occur with psychiatric symptoms. She completed her training in pediatrics, pediatric rheumatology, and clinical epidemiology at Stanford University/LPCH. She directs the Stanford PANS Program (2012- present) where she and her collaborators have created a longitudinal clinical database and large biorepository of patient and control biospecimens. In addition to generating clinical data to better understand the PANS illness, she is collaborating with ten basic science labs who aim to understand the immunological underpinnings of the illness.
1. Give examples of well defined inflammatory disorders that can cause and/or be associated with psychiatric symptoms and name a few of the associated inflammatory markers or physical signs.
2. Recognize the components of PANS that overlap with these other inflammatory diseases.
3. Describe the general approach to infection triggered/associated neuropsychiatric conditions like Sydenham's Chorea, PANDAS, and PANS.