Research Roundup

Research in the field of neuroimmunology will ultimately lead to lasting remission for those affected by these disorders. We are encouraged by the groundbreaking research that continues to further scientific understanding. We have shared some of this research here. Visit our Publications page for additional publications on PANS/PANDAS.

  • Streptococcal Serology in Children With Stuttering

    Sage Journals
    April 9, 2024

  • Postinfectious Inflammation, Autoimmunity, and Obsessive-Compulsive Disorder: Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection, and Pediatric Acute-Onset Neuropsychiatric Disorder

    Karger Developmental Neuroscience 45
    September 22, 2023

  • Prospects and Pitfalls of Plasma Complement C4 in Schizophrenia: Building a Better Biomarker

    Karger Developmental Neuroscience 45
    September 21, 2023

  • Transcranial Magnetic Stimulation for Developmental Neuropsychiatric Disorders with Inflammation

    Karger Developmental Neuroscience 45
    November 9, 2023

  • Clinicopathologic Characteristics of PANDAS in a Young Adult: A Case Report

    Karger Developmental Neuroscience 45
    September 12, 2023

  • Evaluation of C4 Gene Copy Number in Pediatric Acute Neuropsychiatric Syndrome

    Karger Developmental Neuroscience 45
    June 28, 2023

  • Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations in Autism Spectrum Disorder: Insights for Treatment

    Journal of Personalized Medicine
    November 2, 2022

  • Arthritis in Children with Psychiatric Deteriorations: A Case Series

    Karger Developmental Neuroscience 45
    May 12, 2023

  • Autoantibodies in Patients with Obsessive-Compulsive Disorder: A Systematic Review

    Nature | Translational Psychiatry
    July 3, 2023

  • Screen Time and Obsessive-Compulsive Disorder Among Children 9–10 Years Old: A Prospective Cohort Study

    Journal of Adolescent Health
    March 2023

  • Researchers Uncover Mechanisms of Brexanolone and the Role of Inflammation in Post-partum Depression

    “The new finding is monumental in that it suggests that PPD is likely caused, at least in part, by inflammation.”

    UNC Health and UNC School of Medicine
    February 20, 2023

  • Evaluation of Brain-Body Health in Individuals with Common Neuropsychiatric Disorders

    JAMA Psychiatry
    April 26, 2023

  • Autoimmune Encephalitis Criteria in Clinical Practice

    Neurology: Clinical Practice
    April 25, 2023

  • Immunosuppressants Linked to Severe Reactions in People with Common Genetic Profile

    Stanford Medicine
    November 17, 2021

  • Neuroimmune Cell Signaling in Covid-19

    Frontiers in Immunology
    Research Topic 2022–2023

  • Further Understanding of Neuro-Immune Interactions in Allergy: Implications in Pathophysiology and Role in Disease Progression

    DovePress
    September 10, 2022

  • Tractography-based Versus Anatomical Landmark-Based Targeting in Valic Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder

    Molecular Psychiatry
    September 7, 2022

  • Elevated Biomarkers Associated with PASC Phenotype

    NeurologyToday
    September 5, 2022

  • In Vivo Detection of Macromolecule Free Radicals in Mouse Sepsis-Associated Encephalopathy Using a New MRI and Immunospin Trapping Strategy

    DovePress
    September 1, 2022

  • How the Brain’s Housekeeper Malfunctions During Bacterial Meningitis

    EurekAlert!
    August 29, 2022

  • A New Lyme Disease Test in Development May Help Improve Treatment

    Science Friday
    August 26, 2022

  • Pneumolysin Boosts the Neuroinflammatory Response to Streptococcus Pneumoniae Through Enhanced Endocytosis

    Nature Communications
    August 26, 2022

  • Research Round-up: Depression

    Nature
    August 24, 2022

  • Cytokine Dynamics and Targeted Immunotherapies in Autoimmune Encephalitis

    BRAIN Communications
    August 20, 2022

  • Cytokine Profile of Pediatric Patients with Obsessive-Compulsive and/or Movement Disorder Symptoms: A Review

    Frontiers in Pediatrics
    August 19, 2022

  • Study Shows Viruses Can Kill Gut Bacteria of Crohn’s, Bowel Disease

    Israel21c
    August 16, 2022

  • Vitamin D supplements may help reduce chronic inflammation, study finds

    Medical News Today
    August 15, 2022

  • Vitamin D Supplements’ Link to Depression Investigated in New Meta-Analysis

    Technology Networks
    August 15, 2022

  • Epidural Nerve Block with Lidocaine Leads to Clearance of Psoriatic Skin Lesions

    EurekAlert!
    August 10, 2022

  • Biallelic PAX5 Mutations Cause Hypogammaglobulinemia, Sensorimotor Deficits, and Autism Spectrum Disorder

    Journal of Experimental Medicine
    August 10, 2022

  • Neuroinflammation Microstructural Evidence: Psychological Symptoms & Pain in Fibromyalgia

    Physicians Weekly
    August 9, 2022

  • Reflecting on the Immunopathology of Arthritis Associated with Inflammatory Bowel Disease: What Do We Know and What Should We Know?

    PubMed.gov
    May 11, 2022

  • Association of Pediatric Acute-Onset Neuropsychiatric Syndrome with Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging

    JAMA Network
    May 4, 2020

  • Antibodies May Provide a New Treatment for OCD

    National Herald
    April 22, 2020

  • Schizophrenia is Associated With an Aberrant Immune Response to Epstein-Barr Virus

    PubMed.gov
    September 11, 2019

  • Efficacy of Adjunctive Infliximab vs Placebo in the Treatment of Adults With Bipolar I/II Depression

    JAMA Psychiatry
    May 8, 2019

  • Association of Exposure to Infections in Childhood With Risk of Eating Disorders in Adolescent Girls

    JAMA Psychiatry
    April 24, 2019

  • Montelukast and Neuropsychiatric Events in Children with Asthma: A Nested Case-control Study

    Journal of Pediatrics
    March 21, 2019

  • Immunoglobulin A Dysgammaglobulinemia Is Associated with Pediatric-Onset Obsessive-Compulsive Disorder

    PubMed Central
    March 20, 2019

  • Case Study: Bartonella and Sudden-Onset Adolescent Schizophrenia

    NC State University
    March 18, 2019

  • Psychotic Symptoms in Youth with Pediatric Acute-onset Neuropsychiatric Syndrome (Pans) May Reflect Syndrome Severity and Heterogeneity

    PubMed Central
    March 18, 2019

  • Microbes and Monoamines: Potential Neuropsychiatric Consequences of Dysbiosis

    ScienceDirect
    February 26, 2019

  • Recurrent Group A Streptococcus Tonsillitis is an Immunosusceptibility Disease Involving Antibody Deficiency and Aberrant ᵗᶠH Cells

    Science Translational Medicine
    February 6, 2019

  • The Gut Microbiome from Patients with Schizophrenia Modulates the Glutamate-Glutamine-GABA Cycle and Schizophrenia-Relevant Behaviors in Mice

    Science Advances
    February 6, 2019

  • Maternal Thyroid Autoimmunity Associated with Acute‐onset Neuropsychiatric Disorders and Global Regression in Offspring

    Wiley Case Series
    February 5, 2019

  • Rapamycin Alleviates Inflammation by Up-Regulating Tgf-Β/Smad Signaling in a Mouse Model of Autoimmune Encephalomyelitis

    PubMed Central
    January 30, 2019

  • Psychotic Symptoms in Youth with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) May Reflect Syndrome Severity and Heterogeneity

    Journal of Psychiatric Research
    December 31, 2018

  • The Burden of Caring for a Child or Adolescent With Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): An Observational Longitudinal Study

    PubMed.gov
    December 11, 2018

  • GABA-Modulating Bacteria of the Human Gut Microbiota

    Nature Microbiology
    December 10, 2018

  • Aspirin Ameliorates Experimental Autoimmune Encephalomyelitis Through Interleukin-11–mediated Protection of Regulatory T Cells

    Science Signaling
    November 27, 2018

  • Herpes Simplex Virus 1 Infection and Valacyclovir Treatment in Schizophrenia: Results from the Vista Study

    ScienceDirect
    November 23, 2018

  • Mast Cells at the Crossroads of Microbiota and IBD

    European Journal of Microbiology
    November 9, 2018

  • Neuropsychiatric Lupus with Antibody-mediated Striatal Encephalitis

    American Journal of Neuroradiology
    November 2018

  • An Atypical Presentation of Pediatric Acute Neuropsychiatric Syndrome Responding to Plasmapheresis Treatment

    PubMed Central
    June 28, 2018

  • Neuroimmune Disorders of the Central Nervous System in Children in the Molecular Era

    Nature Reviews Neurology
    June 20, 2018

  • Anti-neuronal and Anti-microbial Immunity Link CaMKII and Autism Spectrum Disorder with Pediatric Acute-onset Neuropsychiatric Syndrome

    Journal of Immunology
    May 1, 2018

  • Advances in Biomarker-guided Therapy for Pediatric- and Adult-onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines

    PubMed Central
    March 5, 2018

  • A Clinical Approach to New-Onset Psychosis Associated with Immune Dysregulation: The Concept of Autoimmune Psychosis

    PubMed Central
    February 13, 2018

  • Successful Treatment of Postural Orthostatic Tachycardia and Mast Cell Activation Syndromes Using Naltrexone, Immunoglobulin and Antibiotic Treatment

    PubMed Central
    January 11, 2018

  • Autoimmune Encephalitis with GABAₐ Receptor Antibodies in a 10-year-old Girl

    ScienceDirect
    December 22, 2017

  • Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in PANS: An Observational Study of Patients Followed by an Academic Community-Based PANS Clinic

    PubMed Central
    September 1, 2017

  • Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part III—Treatment and Prevention of Infections

    Journal of Child and Adolescent Psychopharmacology
    September 1, 2017

  • Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome: Part II—Use of Immunomodulatory Therapies

    Journal of Child and Adolescent Psychopharmacology
    September 1, 2017

  • Neurotransmitters: the Critical Modulators Regulating Gut-Brain Axis

    PubMed Central
    April 10, 2017

  • Effects of Bumetanide on Neurobehavioral Function in Children and Adolescents with Autism Spectrum Disorders

    Translational Psychiatry
    March 14, 2017

  • Autoimmune Encephalopathies

    PubMed Central
    October 14, 2014

  • The Dopaminergic System in Autoimmune Diseases

    PubMed Central
    March 21, 2014

  • Anti-N-methyl-D-aspartate (NMDA) Receptor Encephalitis: an Unusual Cause of Autistic Regression in a Toddler

    PubMed.gov
    October 3, 2013

  • IL-1β And TNF-α Induce Neurotoxicity Through Glutamate Production: a Potential Role for Neuronal Glutaminase

    PubMed.gov
    May 3, 2013

  • Frequency of Neuro-Psychiatric Dysfunction in Anti-SSA/SSB Exposed Children With and Without Neonatal Lupus

    PubMed.gov
    December 14, 2009